Aneugen

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An aneugen is a substance that causes a daughter cell to have an abnormal number of chromosomes or aneuploidy. A substance's aneugenicity reflects its ability to induce aneuploidy.[1] Unlike clastogens, aneugenic events do not damage the physical structure of the chromosome, but represent a deletion or insertion of an additional copy of a whole chromosome (i.e. with an intact Centromere). Aneugens and clastogens can be differentiated via certain stains, using the technique of Fluorescence in situ hybridization.

Males, if exposed to certain environmental and/or occupational chemical hazards may face an increased risk of spermatozoa aneuploidy.[2] Tobacco smoke contains chemicals that cause DNA damage (see Tobacco smoking#Health).[3] Smoking also can induce aneuploidy. In this study of men with a moderate smoking habit showed an association with increased chromosome 13 disomy in spermatozoa by 3-fold[4] and YY disomy by 2-fold.[5]

Occupational exposure to benzene is associated with a 2.8-fold increase of XX disomy and a 2.6-fold increase of YY disomy in spermatozoa.[6]

Pesticides are released to the environment in large quantities so that most individuals have some degree of exposure. The insecticides fenvalerate and carbaryl have been reported to increase spermatozoa aneuploidy. Occupational exposure of pesticide factory workers to fenvalerate is associated with increased spermatozoa DNA damage.[7] Exposure to fenvalerate raised sex chromosome disomy 1.9-fold and disomy of chromosome 18 by 2.6-fold (Xia et al., 2004). Exposure of male workers to carbaryl increased DNA fragmentation in spermatozoa, and also increased sex chromosome disomy by 1.7-fold and chromosome 18 disomy by 2.2-fold.[8]

Humans are exposed to perfluorinated compounds (PFCs) in many commercial products.[9] Men contaminated with PFCs in whole blood or seminal plasma have spermatozoa with increased levels of DNA fragmentation and chromosomal aneuploidies.[9]

See also

References

  1. ^ Plante, N. (2003). Molecular toxicology. Taylor & Francis. pp. 63–65. ISBN 978-1-85996-345-6. Retrieved 12 April 2013.
  2. ^ Templado C, Uroz L, Estop A (2013). "New insights on the origin and relevance of aneuploidy in human spermatozoa". Mol. Hum. Reprod. 19 (10): 634–43. doi:10.1093/molehr/gat039. PMID 23720770.
  3. ^ Humans, IARC Working Group on the Evaluation of Carcinogenic Risks to (2012), "TOBACCO SMOKING", Personal Habits and Indoor Combustions, International Agency for Research on Cancer, retrieved 2024-02-16
  4. ^ Shi Q, Ko E, Barclay L, Hoang T, Rademaker A, Martin R (2001). "Cigarette smoking and aneuploidy in human sperm". Mol. Reprod. Dev. 59 (4): 417–21. doi:10.1002/mrd.1048. PMID 11468778. S2CID 35230655.
  5. ^ Rubes J, Lowe X, Moore D, Perreault S, Slott V, Evenson D, Selevan SG, Wyrobek AJ (1998). "Smoking cigarettes is associated with increased sperm disomy in teenage men". Fertil. Steril. 70 (4): 715–23. doi:10.1016/S0015-0282(98)00261-1. PMID 9797104.
  6. ^ Xing C, Marchetti F, Li G, Weldon RH, Kurtovich E, Young S, Schmid TE, Zhang L, Rappaport S, Waidyanatha S, Wyrobek AJ, Eskenazi B (2010). "Benzene exposure near the U.S. permissible limit is associated with sperm aneuploidy". Environ. Health Perspect. 118 (6): 833–9. doi:10.1289/ehp.0901531. PMC 2898861. PMID 20418200.
  7. ^ Bian Q, Xu LC, Wang SL, Xia YK, Tan LF, Chen JF, Song L, Chang HC, Wang XR (2004). "Study on the relation between occupational fenvalerate exposure and spermatozoa DNA damage of pesticide factory workers". Occup Environ Med. 61 (12): 999–1005. doi:10.1136/oem.2004.014597. PMC 1740696. PMID 15550606.
  8. ^ Xia Y, Cheng S, Bian Q, Xu L, Collins MD, Chang HC, Song L, Liu J, Wang S, Wang X (2005). "Genotoxic effects on spermatozoa of carbaryl-exposed workers". Toxicol. Sci. 85 (1): 615–23. doi:10.1093/toxsci/kfi066. PMID 15615886.
  9. ^ a b Governini L, Guerranti C, De Leo V, Boschi L, Luddi A, Gori M, Orvieto R, Piomboni P (2015). "Chromosomal aneuploidies and DNA fragmentation of human spermatozoa from patients exposed to perfluorinated compounds". Andrologia. 47 (9): 1012–9. doi:10.1111/and.12371. PMID 25382683. S2CID 13484513.
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