Alzheimer's Disease Cooperative Study
The Alzheimer's Disease Cooperative Study (ADCS) was founded at University of California San Diego in 1991 and coordinates clinical trials of candidate treatments for Alzheimer's disease.
It is funded by the National Institutes of Health as well as companies that develop drugs. The center has coordinated important clinical trials on AD drugs like solanezumab.[2]
History
As of 2008, 75 research sites in the United States and Canada were part of the consortium. Leon Thal served as director until February 2007, when he died; Paul Aisen was recruited to succeed him.
In 2006, the NIH awarded $52 million to ADCS to fund 6 years of further clinical trials.[3]
In 2013 Eli Lilly committed to spending $76.6 million on clinical trials through the center.[4]
Aisen left UCSD in 2015 because he was unhappy with the level of support that UCSD was providing him and due to USC's offer.[5] UCSD and USC ended up in litigation over control of the ADCS and its research data, which at that time involved six ongoing clinical trials and data collected on thousands of clinical trial subjects.[6][7] Part of the dispute arose because Aisen's lab had uploaded the data from the ADCS onto Amazon Cloud servers and would not give the passwords to UCSD officials.[2][8][9] Some aspects of data management were temporarily settled in 2016;[10] as of 2017 the litigation was ongoing.[11][12] The lawsuit was settled in 2019.[13]
They are currently involved in several ongoing studies, such as the VIVA-MIND trial and the BenfoTeam study[14]
References
- ↑ "Dementia". www.who.int. Archived from the original on 24 August 2019. Retrieved 21 November 2024. Archived 24 August 2019 at the Wayback Machine
- ↑ 2.0 2.1 Garde, Damian (August 5, 2015). "Judge orders a halt to Alzheimer's spat as Eli Lilly chooses sides in dispute". FierceBiotech. Archived from the original on August 31, 2017. Retrieved November 21, 2024. Archived August 31, 2017, at the Wayback Machine
- ↑ "Paul Aisen, MD, Joins Faculty of UCSD and is Appointed New Director of the Alzheimer's Disease Cooperative Study". Journal of Investigative Medicine. 56 (1): 3. January 2008. doi:10.1097/01.JIM.0000308082.54350.ba.
- ↑ Terry, Mark (July 22, 2015). "Eli Lilly Increases San Diego R&D Space by 140%, Staff by 70%". BioSpace via PharmaLive. Archived from the original on July 1, 2018. Retrieved November 21, 2024. Archived July 1, 2018, at the Wayback Machine
- ↑ Fikes, Bradley J. (5 July 2015). "UC San Diego sues USC and scientist, alleging conspiracy to take funding, data". Los Angeles Times.
- ↑ Check Hayden, Erika (16 July 2015). "Alzheimer's data lawsuit is sign of growing tensions". Nature. 523 (7560): 265. doi:10.1038/nature.2015.17932.
- ↑ Basken, Paul (23 July 2015). "Grant Dispute Throws an Unwritten Rule of Academic Poaching Out the Window". The Chronicle of Higher Education. Archived from the original on 22 March 2018. Retrieved 21 November 2024. Archived 22 March 2018 at the Wayback Machine
- ↑ Fikes, Bradley J. (2 August 2015). "Next steps for scientist in eye of UCSD-USC Alzheimer's spat". San Diego Tribune. Archived from the original on 5 September 2017. Retrieved 21 November 2024. Archived 5 September 2017 at the Wayback Machine
- ↑ Wang, Shirley S.; Loftus, Peter (14 October 2015). "Alzheimer's Research Effort Is Ensnared in Legal Dispute". Wall Street Journal. Archived from the original on 13 June 2023. Retrieved 21 November 2024. Archived 13 June 2023 at the Wayback Machine
- ↑ Potter, Matt (January 11, 2016). "Deal gives UCSD "read only" rights to Alzheimer's data". San Diego Reader. Archived from the original on July 17, 2024. Retrieved November 21, 2024. Archived July 17, 2024, at the Wayback Machine
- ↑ "Case 3:15-cv-01766: The Regents of the University of California v. Aisen et al (3:15-cv-01766), California Southern District Court". PacerMonitor. Archived from the original on 31 August 2017. Retrieved 15 June 2017. Archived 31 August 2017 at the Wayback Machine
- ↑ "Case 8:17-cv-00721: The Regents of the University of California v. Aisen et al (8:17-cv-00721), Maryland District Court". PacerMonitor. Archived from the original on 31 August 2017. Retrieved 15 June 2017. Archived 31 August 2017 at the Wayback Machine
- ↑ "USC pays UCSD $50M, and gives the school an apology, for raiding its Alzheimer's program". San Diego Union-Tribune. 2019-07-04. Archived from the original on 2022-09-14. Retrieved 2022-09-14. Archived 2022-09-14 at the Wayback Machine
- ↑ "ADCS Home". ADCS. Archived from the original on 19 November 2024. Retrieved 21 November 2024. Archived 19 November 2024 at the Wayback Machine