Aluminum hydroxide/magnesium hydroxide/simethicone

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Aluminum hydroxide/magnesium hydroxide/simethicone
Combination of
Aluminum hydroxideAntacid
Magnesium hydroxideAntacid
Trade namesAlmagel Plus,[1] Diovol Plus,[2] Maalox, Mylanta, others[3]
Clinical data
Main usesHeart burn, indigestion, abdominal bloating, discomfort from overeating[4][3]
Side effectsDiarrhea, constipation, low potassium[1][3]
InteractionsDigoxin, phenytoin, tetracyclines, quinolones[1]
BreastfeedingAl OH (safe)[5][6]
Mg OH (safe)[7]
Simethicone (safe)[8]
Legal status

Aluminum hydroxide/magnesium hydroxide/simethicone is a combination medicine used to help with heart burn, indigestion, abdominal bloating, and discomfort from overeating.[4][3] It is available as a liquid or pill, which is taken by mouth.[3]

Side effects may include diarrhea, constipation, or low potassium.[1][3] It may decrease the absorption of other medications.[3] Care should be taken in people with kidney problems.[1] Use is regarded as okay when breastfeeding.[9][10] The components aluminum hydroxide and magnesium hydroxide are antacids while simethicone decreases intestinal gas.[2] The benefit of having both aluminum and magnesium antacids is that there is generally little change in bowel movements.[11]

In the United States a 350 ml bottle costs about 10 USD as of 2023 and is available over the counter.[12] It is sold under more than 50 brand names including Diovol Plus and Maalox.[2][3] Different flavors are available.[3]

Medical uses


The typical dose is 10 to 20 mL up to four times per day.[1]

Society and culture


The cost of this medication in the U.S. is $12 (USD) for 355 ml oral suspension 200 mg-200 mg-20 mg/5 mL.[12]


  1. 1.0 1.1 1.2 1.3 1.4 1.5 "CW Online Formulary". Archived from the original on 4 July 2020. Retrieved 12 May 2023.
  2. 2.0 2.1 2.2 "Aluminum/Magnesium Antacid/Simethicone - Oral". Archived from the original on 29 January 2023. Retrieved 12 May 2023.
  3. 3.0 3.1 3.2 3.3 3.4 3.5 3.6 3.7 3.8 "Aluminum hydroxide, magnesium hydroxide, and simethicone Uses, Side Effects & Warnings". Archived from the original on 28 January 2021. Retrieved 12 May 2023.
  4. 4.0 4.1 "DailyMed - MINTOX- aluminum hydroxide, magnesium hydroxide, simethicone suspension". Retrieved 12 May 2023.
  5. "Aluminum hydroxide Use During Pregnancy". Archived from the original on 21 October 2020. Retrieved 13 April 2021.
  6. "BREASTFEEDING AND MATERNAL MEDICATION Recommendations for Drugs in the Eleventh WHO Model List of Essential Drugs". Archived from the original on 27 August 2021. Retrieved 14 April 2021.
  7. "Magnesium Hydroxide". Drugs and Lactation Database (LactMed). National Library of Medicine (US). 2006. Archived from the original on 5 March 2021. Retrieved 13 April 2021.
  8. "Aluminum hydroxide / magnesium hydroxide / simethicone Use During Pregnancy". Archived from the original on 20 January 2021. Retrieved 13 April 2021.
  9. Mannel, Rebecca; Martens, Patricia J.; Walker, Marsha (18 June 2012). Core Curriculum for Lactation Consultant Practice. Jones & Bartlett Publishers. p. 443. ISBN 978-0-7637-9879-6.
  10. "Aluminum hydroxide / magnesium hydroxide / simethicone Use During Pregnancy". Archived from the original on 20 January 2021. Retrieved 13 May 2023.
  11. Acosta, W. Renee (8 June 2020). Pharmacology for Health Professionals. Jones & Bartlett Learning. p. 269. ISBN 978-1-284-24083-2.
  12. 12.0 12.1 "Aluminum hydroxide/magnesium hydroxide/simethicone Prices, Coupons & Patient Assistance Programs". Archived from the original on 10 April 2021. Retrieved 13 April 2023.

External links