All-trans-retinyl-palmitate hydrolase

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retinoid isomerohydrolase
Identifiers
EC no.3.1.1.64
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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PMCarticles
PubMedarticles
NCBIproteins

The enzyme retinoid isomerohydrolase (EC 3.1.1.64, all-trans-retinyl-palmitate hydrolase) catalyzes the reaction

an all-trans-retinyl ester + H2O = 11-cis-retinol + a fatty acid

This enzyme belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. The systematic name is all-trans-retinyl ester acylhydrolase, 11-cis retinol-forming. This enzyme participates in retinol metabolism.

References

  • Blaner WS, Das SR, Gouras P, Flood MT (1987). "Hydrolysis of 11-cis- and all-trans-retinyl palmitate by homogenates of human retinal epithelial cells". J. Biol. Chem. 262 (1): 53–8. PMID 3793734.