Adenovirus vaccine

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Adenovirus vaccine
TEVA adenovirus.jpg
Bottles of the vaccine
Vaccine description
Target diseaseAdenovirus
TypeLive virus
Clinical data
Main usesPrevent adenovirus infection[1]
Side effectsHeadache, runny nose, cough, joint pain, nausea, diarrhea[2]
Pregnancy
category
  • US: N (Not classified yet)
Routes of
use
By mouth
External links
AHFS/Drugs.comMonograph
US NLMAdenovirus vaccine
Legal
License data

Adenovirus vaccine is a vaccine against certain types of adenovirus infection.[1][3] Specifically it is effective against Type 4 and Type 7.[1] It is taken by mouth.[1]

Common side effects include headache, runny nose, cough, joint pain, nausea, and diarrhea.[2] Use in contraindicated in pregnancy.[2] It consists of live (not attenuated) virus.[2] The tablets are coated, so that the virus passes the stomach and infects the intestines, where immunity is raised.[2][4]

Adenovirus vaccine was approved for medical use by the United States military in the United States in 2011.[2] Prior versions were used by the military starting in 1960.[1][5][6]

History

It was used by the United States military from 1971 to 1999, but was discontinued when the only manufacturer stopped production.[7][8] On March 16, 2011, the U.S. Food and Drug Administration approved an adenovirus vaccine manufactured by Teva Pharmaceuticals under contract to the U.S. Army.[9] This vaccine is essentially the same as the one used from 1971 to 1999. On October 24, 2011, the military services began administering the new adenovirus vaccine to recruits during basic training.[10]

Research

It should not be confused with the strategy of using adenovirus as a viral vector to develop vaccines for other pathogens, or as a general gene carrier.[11][12][13]

References

  1. 1.0 1.1 1.2 1.3 1.4 "Adenovirus Vaccine Information Statement | CDC". www.cdc.gov. 8 April 2021. Retrieved 13 January 2022.
  2. 2.0 2.1 2.2 2.3 2.4 2.5 "DailyMed - ADENOVIRUS TYPE 4 AND TYPE 7 VACCINE, LIVE kit". dailymed.nlm.nih.gov. Retrieved 13 January 2022.
  3. Tucker SN, Tingley DW, Scallan CD (February 2008). "Oral adenoviral-based vaccines: historical perspective and future opportunity". Expert Rev Vaccines. 7 (1): 25–31. doi:10.1586/14760584.7.1.25. PMID 18251691. S2CID 7058518.
  4. "Adenovirus Vaccine Monograph for Professionals". Drugs.com. Retrieved 13 January 2022.
  5. Volberding, Paul; Palefsky, Joel M. (2006). Viral and Immunological Malignancies. PMPH-USA. p. 318. ISBN 978-1-55009-256-1.
  6. Plotkin, Stanley A.; Orenstein, Walter A. (2008). Vaccines (Fourth ed.). Elsevier. p. 8. ISBN 978-1-4160-3611-1.
  7. Russell KL, Hawksworth AW, Ryan MA, et al. (April 2006). "Vaccine-preventable adenoviral respiratory illness in US military recruits, 1999-2004". Vaccine. 24 (15): 2835–42. doi:10.1016/j.vaccine.2005.12.062. PMC 1955759. PMID 16480793.
  8. "Vaccine Trials For "Boot Camp Crud" May Help 20 Percent of Recruits". Archived from the original on 12 February 2009. Retrieved 15 January 2009.
  9. Malarkey MA, Baylor NW. FDA approval letter dated March 16, 2011.
  10. Choudhry A, Mathena J, Albano JD, Yacovone M, Collins L (31 August 2016). "Safety evaluation of adenovirus type 4 and type 7 vaccine live, oral in military recruits". Vaccine. 34 (38): 4558–4564. doi:10.1016/j.vaccine.2016.07.033. PMID 27475474.
  11. Croyle MA, Patel A, Tran KN, et al. (2008). Doolan DL (ed.). "Nasal Delivery of an Adenovirus-Based Vaccine Bypasses Pre-Existing Immunity to the Vaccine Carrier and Improves the Immune Response in Mice". PLOS ONE. 3 (10): e3548. Bibcode:2008PLoSO...3.3548C. doi:10.1371/journal.pone.0003548. PMC 2569416. PMID 18958172.
  12. Hartman ZC, Appledorn DM, Amalfitano A (March 2008). "Adenovirus vector induced innate immune responses: impact upon efficacy and toxicity in gene therapy and vaccine applications". Virus Res. 132 (1–2): 1–14. doi:10.1016/j.virusres.2007.10.005. PMC 4039020. PMID 18036698.
  13. Tatsis N, Ertl HC (October 2004). "Adenoviruses as vaccine vectors". Mol. Ther. 10 (4): 616–29. doi:10.1016/j.ymthe.2004.07.013. PMC 7106330. PMID 15451446.

External links

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