Adapalene/benzoyl peroxide

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Adapalene/benzoyl peroxide
Adapalene and benzoyl peroxide.svg
Combination of
Benzoyl peroxidePeroxide
Trade namesEpiduo, Epiduo Forte
Clinical data
Routes of
Legal status
CAS Number
  • 1194805-81-6 ☒N
ATC code

Adapalene/benzoyl peroxide, sold under the brand name Epiduo among others, is a fixed-dose combination medication for the treatment of severe acne vulgaris.[1][2] It consists of a combination of adapalene and benzoyl peroxide in a topical gel formulation.[1][2]

It is available as a generic medication.[3] In Canada 3 months costs about 220 CAD as of 2021.[4]

Medical uses

Adapalene/benzoyl peroxide is indicated for the topical treatment of acne vulgaris.[1][2]

Side effects

Commonly reported side effects include the following:[1][2]


Meta-analysis of clinical trials has shown this combined therapy to be more effective than either of its ingredients by themselves.[5]

The use of adapalene/benzoyl peroxide in combination with oral antibiotics (lymecycline) has been studied;[6] the combination was well tolerated and showed an improved success rate compared to those receiving only antibiotics (47.6% vs. 33.7%, P = 0.002).


  1. 1.0 1.1 1.2 1.3 1.4 "Epiduo- adapalene and benzoyl peroxide gel". DailyMed. 21 February 2018. Archived from the original on 16 May 2022. Retrieved 15 May 2022.
  2. 2.0 2.1 2.2 2.3 2.4 "Epiduo Forte- adapalene and benzoyl peroxide gel". DailyMed. 27 April 2022. Archived from the original on 16 May 2022. Retrieved 15 May 2022.
  3. "Competitive Generic Therapy Approvals". U.S. Food and Drug Administration (FDA). 3 March 2023. Archived from the original on 12 February 2022. Retrieved 6 March 2023.
  4. Ton, Joey (19 April 2021). "#288 Clearing up the Evidence for Topical Acne Combination Products". CFPCLearn. Archived from the original on 28 March 2023. Retrieved 15 June 2023.
  5. Tan J, Gollnick HP, Loesche C, Ma YM, Gold LS (August 2011). "Synergistic efficacy of adapalene 0.1%-benzoyl peroxide 2.5% in the treatment of 3855 acne vulgaris patients". The Journal of Dermatological Treatment. 22 (4): 197–205. doi:10.3109/09546631003681094. PMID 20666678. S2CID 34631151.
  6. Dréno B, Kaufmann R, Talarico S, Torres Lozada V, Rodríguez-Castellanos MA, Gómez-Flores M, et al. (August 2011). "Combination therapy with adapalene-benzoyl peroxide and oral lymecycline in the treatment of moderate to severe acne vulgaris: a multicentre, randomized, double-blind controlled study". The British Journal of Dermatology. 165 (2): 383–90. doi:10.1111/j.1365-2133.2011.10374.x. PMID 21495995. S2CID 21793660.

External links