|Other names||Acute bacterial prostatitis|
|Symptoms||Sudden onset pelvic pain, fever, pain with urination|
|Complications||Urinary retention, prostate abscess, sepsis, chronic prostatitis|
|Usual onset||20s or 30s|
|Risk factors||Urinary tract infection, urinary catheter, prostate biopsy, sexually transmitted infection, anal sex|
|Diagnostic method||Based on symptoms, examination, urine testing|
|Differential diagnosis||Pyelonephritis, urethritis, prostate cancer|
|Treatment||Antibiotics, pain medication|
Acute prostatitis is a type of prostatitis which is sudden in onset. Symptoms may include significant pelvic or lower back pain, fever, and pain with urination. Complications may include urinary retention, prostate abscess, sepsis, and chronic prostatitis.
Acute prostatitis is usually due to a bacterial infection of the prostate gland. While various types of bacteria may be involved, E. coli is most common. Risk factors include urinary tract infections, urinary catheters, prostate biopsy, sexually transmitted infections, and anal sex. Diagnosis is generally based on symptoms, examination and urine testing. Doing a prostate massage during the exam is not recommended.
Treatment is generally with antibiotics for two to four weeks. Pain medications may also be required. A urinary catheter may be placed if retention is present. Alpha blockers and NSAIDs may be useful to decrease the swelling. Outcomes are usually good with treatment.
Signs and symptoms
Men with acute prostatitis often have chills, fever, pain in the lower back, perineum, or genital area, urinary frequency and urgency often at night, burning or painful urination, body aches, and a demonstrable infection of the urinary tract, as evidenced by white blood cells and bacteria in the urine. Acute prostatitis may be a complication of prostate biopsy. Often, the prostate gland is very tender to palpation through the rectum.
Acute prostatitis is relatively easy to diagnose due to its symptoms that suggest infection. The organism may be found in blood or urine, and sometimes in both. Common bacteria are Escherichia coli, Klebsiella, Proteus, Pseudomonas, Enterobacter, Enterococcus, Serratia, and Staphylococcus aureus. This can be a medical emergency in some patients and hospitalization with intravenous antibiotics may be required. A complete blood count reveals increased white blood cells. Sepsis from prostatitis is very rare, but may occur in immunocompromised patients; high fever and malaise generally prompt blood cultures, which are often positive in sepsis. A prostate massage should never be done in a patient with suspected acute prostatitis, since it may induce sepsis. Since bacteria causing the prostatitis is easily recoverable from the urine, prostate massage is not required to make the diagnosis. Rectal palpation usually reveals an enlarged, exquisitely tender, swollen prostate gland, which is firm, warm, and, occasionally, irregular to the touch. C-reactive protein is elevated in most cases.
Prostate biopsies are not indicated as the (clinical) features (described above) are diagnostic. The histologic correlate of acute prostatitis is a neutrophilic infiltration of the prostate gland.
Acute prostatitis is associated with a transiently elevated PSA, i.e., the PSA is increased during an episode of acute prostatitis and then decreases again after it has resolved. PSA testing is not indicated in the context of uncomplicated acute prostatitis. Other diagnostic methods include ultrasound.
Abscess of the prostate (red arrow) resulting in urinary retention (blue arrow)
Antibiotics are the first line of treatment in acute prostatitis. Antibiotics usually resolve acute prostatitis infections in a very short time, however a minimum of two to four weeks of therapy is recommended to eradicate the offending organism completely. Appropriate antibiotics should be used, based on the microbe causing the infection. Some antibiotics have very poor penetration of the prostatic capsule, others, such as ciprofloxacin, trimethoprim/sulfamethoxazole, and tetracyclines such as doxycycline penetrate prostatic tissue well. In acute prostatitis, penetration of the prostate is not as important as for category II because the intense inflammation disrupts the prostate-blood barrier. It is more important to choose a bactericidal antibiotic (kills bacteria, e.g., a fluoroquinolone antibiotic) rather than a bacteriostatic antibiotic (slows bacterial growth, e.g. tetracycline) for acute potentially life-threatening infections.
People who are severely ill may need hospitalization, while others can be treated at home with bed rest, analgesics, stool softeners, and hydration. Men with acute prostatitis complicated by urinary retention are best managed with a suprapubic catheter or intermittent catheterization. Lack of response to antibiotics should raise the suspicion of an prostate abscess and prompt an imaging study such as a transrectal ultrasound (TRUS).
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