Aculeacin-A deacylase

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Aculeacin-A deacylase
Identifiers
EC no.3.5.1.70
CAS no.121479-50-3
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
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NCBIproteins

In enzymology, an aculeacin-A deacylase (EC 3.5.1.70) is an enzyme that catalyzes the chemical reaction that cleaves the amide bond in aculeacin A and related neutral lipopeptide antibiotics, releasing the long-chain fatty acid side chain.

This enzyme belongs to the family of hydrolases, specifically those acting on carbon-nitrogen bonds other than peptide bonds in linear amides. The systematic name of this enzyme class is aculeacin-A amidohydrolase. This enzyme is also called aculeacin A acylase.

References

  • Takeshima H, Inokoshi J, Takada Y, Tanaka H, Omura S (April 1989). "A deacylation enzyme for aculeacin A, a neutral lipopeptide antibiotic, from Actinoplanes utahensis: purification and characterization". J. Biochem. 105 (4). Tokyo: 606–10. PMID 2760018.