Acetylsalicylate deacetylase
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| acetylsalicylate deacetylase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 3.1.1.55 | ||||||||
| CAS no. | 87348-04-7 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
The enzyme acetylsalicylate deacetylase (EC 3.1.1.55) catalyzes the reaction
- acetylsalicylate + H2O salicylate + acetate
This enzyme belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. The systematic name is acetylsalicylate O-acetylhydrolase. Other names in common use include aspirin esterase, acetylsalicylic acid esterase, and aspirin hydrolase.
References
- Ali B, Kaur S (1983). "Mammalian tissue acetylsalicylic acid esterase(s): identification, distribution and discrimination from other esterases". J. Pharmacol. Exp. Ther. 226 (2): 589–94. PMID 6875867.
- Kim DH, Yang YS, Jakoby WB (1990). "Aspirin hydrolyzing esterases from rat liver cytosol". Biochem. Pharmacol. 40 (3): 481–7. doi:10.1016/0006-2952(90)90546-W. PMID 2383281.
- White KN, Hope DB (1984). "Partial purification and characterization of a microsomal carboxylesterase specific for salicylate esters from guinea-pig liver". Biochim. Biophys. Acta. 785 (3): 138–47. doi:10.1016/0167-4838(84)90138-9. PMID 6704404.
