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Pemphigus vulgaris

Acantholysis is the loss of intercellular connections, such as desmosomes, resulting in loss of cohesion between keratinocytes,[1] seen in diseases such as pemphigus vulgaris.[2] It is absent in bullous pemphigoid, making it useful for differential diagnosis.

It is also seen in Darier disease and Grover's disease.[3]

This histological feature is also seen in herpes simplex infections (HSV 1 and 2) and varicella zoster infections (chicken pox and shingles).

Biopsy section from trunk showing suprabasal acantholysis

See also


  1. Kumar, Vinay; Fausto, Nelso; Abbas, Abul (2004) Robbins & Cotran Pathologic Basis of Disease (7th ed.). Saunders. Page 1230. ISBN 0-7216-0187-1.
  2. "Acantholysis - Medical Definition from MediLexicon". Archived from the original on 2016-07-31. Retrieved 2017-04-22.
  3. Johnstone, Ronald B. (2017). "1. The basics". Weedon's Skin Pathology Essentials (2nd ed.). Elsevier. p. 3. ISBN 978-0-7020-6830-0. Archived from the original on 2024-02-15. Retrieved 2024-02-15.

External links