AZGP1

AZGP1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1T7V, 1T7W, 1T7X, 1T7Y, 1T7Z, 1T80, 1ZAG, 3ES6
Identifiers
Aliases	AZGP1, ZA2G, ZAG, alpha-2-glycoprotein 1, zinc-binding
External IDs	OMIM: 194460 MGI: 103163 HomoloGene: 915 GeneCards: AZGP1
Gene location (Human)
Chr.	Chromosome 7 (human)
End	99,976,042 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	137,988,495 bp
RNA expression pattern
	Top expressed in
	parotid gland; ; right lobe of liver; ; trachea; ; body of pancreas; ; lactiferous duct; ; skin of abdomen; ; prostate; ; minor salivary glands; ; urethra; ; nipple;
	Top expressed in
	left lobe of liver; ; gallbladder; ; lacrimal gland; ; superior surface of tongue; ; parotid gland; ; proximal tubule; ; olfactory epithelium; ; epithelium of stomach; ; kidney; ; pyloric antrum;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein transmembrane transporter activity; ribonuclease activity; protein binding;
Cellular component	plasma membrane; extracellular exosome; nucleus; extracellular space; extracellular matrix; extracellular region; collagen-containing extracellular matrix; external side of plasma membrane;
Biological process	detection of chemical stimulus involved in sensory perception of bitter taste; retina homeostasis; cell adhesion; transmembrane transport; negative regulation of cell population proliferation; protein transmembrane transport; RNA phosphodiester bond hydrolysis; immune response;
	Sources:Amigo / QuickGO
Orthologs
	563
	12007
	ENSG00000160862
	ENSMUSG00000037053
	P25311
	Q64726
	NM_001185
	NM_013478
	NP_001176
	NP_038506
	Wikidata
View/Edit Human	View/Edit Mouse

Zinc-alpha-2-glycoprotein is a protein that in humans is encoded by the AZGP1 gene.^[5]^[6]

This gene expresses a soluble protein that stimulates lipolysis, induces a reduction in body fat in mice, is associated with the cachexia related to cancer, and is known to be expressed in secretory cells of lung epithelium.^[7] In 2009, it was found that smoking increases expression of this gene, which is why smoking cessation leads to weight gain.^[7] Zinc-alpha-2-glycoprotein levels also rise with onset of diabetes 2, which accounts for weight loss thereafter.^{[citation needed]}

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000160862 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000037053 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ueyama H, Niwa M, Tada T, Sasaki M, Ohkubo I (Jul 1991). "Cloning and nucleotide sequence of a human Zn-alpha 2-glycoprotein cDNA and chromosomal assignment of its gene". Biochem Biophys Res Commun. 177 (2): 696–703. doi:10.1016/0006-291X(91)91844-3. PMID 2049092.
^ "Entrez Gene: AZGP1 alpha-2-glycoprotein 1, zinc-binding".
^ ^a ^b Vanni H, Kazeros A, Wang R, Harvey BG, Ferris B, De BP, Carolan BJ, Hübner RH, et al. (2009). "Cigarette Smoking Induces Overexpression of a Fat-Depleting Gene AZGP1 in the Human". Chest. 135 (5): 1197–208. doi:10.1378/chest.08-1024. PMC 2679098. PMID 19188554.

External links

Human AZGP1 genome location and AZGP1 gene details page in the UCSC Genome Browser.

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