Ecto-ADP-ribosyltransferase 4 is an enzyme that in humans is encoded by the ART4 gene.  ART4 has also been designated as  CD297 ( cluster of differentiation 297).
This gene encodes a protein that contains a mono-ADP-ribosylation (ART) motif. It is a member of the ADP-ribosyltransferase gene family but enzymatic activity has not been demonstrated experimentally. Antigens of the Dombrock blood group system are located on the gene product, which is glycosylphosphatidylinositol-anchored to the erythrocyte membrane. Allelic variants, some of which lead to adverse transfusion reactions, are known.
Blood group antigens
Several antigens have been recognised in this family. These are DO*A, DO*JO1, DO*A-WL, DO*DOYA, DO*B, DO*B-WL, DO*B-SH-Q149K, DO*B-(WL)-I175N, DO*HY1, DO*HY2 and DO*DOMR.
Mouse Mutant Alleles for Art4
Marker Symbol for Mouse Gene. This symbol is assigned to the genomic locus by the
Mutant Mouse Embryonic Stem Cell Clones. These are the known targeted mutations for this gene in a mouse.
Example structure of targeted conditional mutant allele for this gene
These Mutant ES Cells can be studied directly or used to generate mice with this gene knocked out. Study of these mice can shed light on the function of Art4:
Model organisms have been used in the study of ART4 function. A conditional knockout mouse line called Art4 was generated at the tm1a(KOMP)Wtsi Wellcome Trust Sanger Institute. Male and female animals underwent a standardized  phenotypic screen to determine the effects of deletion.     Additional screens performed: - In-depth immunological phenotyping  - in-depth bone and cartilage phenotyping 
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This article incorporates text from the
United States National Library of Medicine, which is in the public domain.