ALC-0159

ALC-0159

Names
Other names 2-[(polyethylene glycol)-2000]-N,N-ditetradecylacetamide
Identifiers
CAS Number	1849616-42-7
UNII	PJH39UMU6H
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

ALC-0159 is a PEG/lipid conjugate (i.e. PEGylated lipid), specifically, it is the N,N-dimyristylamide of 2-hydroxyacetic acid, O-pegylated to a PEG chain mass of about 2 kilodaltons (corresponding to about 45-46 ethylene oxide units per molecule of N,N-dimyristyl hydroxyacetamide). It is a non-ionic surfactant by its nature. It has been deployed in the Pfizer-BioNTech SARS-CoV-2 mRNA vaccine (0.05 mg per dose) that contains the active ingredient tozinameran.

See also

Pfizer–BioNTech COVID-19 vaccine nanoparticle ingredients

• ALC-0315
• 1,2-distearoyl-sn-glycero-3-phosphocholine
• Cholesterol

Others

• Polyethoxylated tallow amine

References

• Assessment report, Comirnaty, Common name: COVID-19 mRNA vaccine (nucleoside-modified); Procedure No. EMEA/H/C/005735/0000 - gives structural formula for the compound (p. 24)