4-Hydroxycyclophosphamide
Jump to navigation
Jump to search
Identifiers | |
---|---|
| |
CAS Number | |
PubChem CID | |
ChemSpider | |
UNII | |
ChEMBL | |
CompTox Dashboard (EPA) | |
Chemical and physical data | |
Formula | C7H15Cl2N2O3P |
Molar mass | 277.08 g·mol−1 |
3D model (JSmol) | |
| |
| |
(what is this?) (verify) |
4-Hydroxycyclophosphamide is in the class of oxazaphosphorine compounds, and is the main, active metabolite of cyclophosphamide and of mafosfamide after they partially metabolized by cytochrome P450. It is then partially tautomerized into aldophosphamide, which, in turn, easily enters live cells and then is partially detoxified into inactive carboxycyclophosphamide by the enzyme ALDH, but partially is hydrolyzed by another cell's enzyme phosphatase to the two directly cytotoxic metabolites - phosphoramide mustard and acrolein.[1]
References
- ^ Ludeman SM (August 1999). "The chemistry of the metabolites of cyclophosphamide". Current Pharmaceutical Design. 5 (8): 627–43. doi:10.2174/1381612805666230110215458. PMID 10469895.
Categories:
- Articles with short description
- Short description matches Wikidata
- Articles with changed CASNo identifier
- Articles with changed ChemSpider identifier
- Articles with changed EBI identifier
- Articles with changed InChI identifier
- Chemical pages without DrugBank identifier
- Articles without KEGG source
- Drugs missing an ATC code
- Drugs with no legal status
- Drugboxes which contain changes to verified fields
- Drugboxes which contain changes to watched fields
- All stub articles
- Antineoplastic and immunomodulating drug stubs
- Organochlorides
- IARC Group 1 carcinogens
- Oxazaphosphinans
- Nitrogen mustards
- Phosphorodiamidates
- Chloroethyl compounds