(RNA-polymerase)-subunit kinase

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RNA polymerase subunit kinase
Identifiers
EC no.2.7.11.23
CAS no.122097-00-1
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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PMCarticles
PubMedarticles
NCBIproteins

In enzymology, an [RNA-polymerase]-subunit kinase (EC 2.7.11.23) is an enzyme that catalyzes the chemical reaction

ATP + [DNA-directed RNA polymerase] ADP + phospho-[DNA-directed RNA polymerase]

Thus, the two substrates of this enzyme are ATP and DNA-directed RNA polymerase, whereas its two products are ADP and phospho-DNA-directed RNA polymerase.

This enzyme belongs to the family of transferases, specifically those transferring a phosphate group to the sidechain oxygen atom of serine or threonine residues in proteins (protein-serine/threonine kinases). The systematic name of this enzyme class is ATP:[DNA-directed RNA polymerase] phosphotransferase. Other names in common use include CTD kinase, and STK9.

References

  • Lee JM, Greenleaf AL (1989). "A protein kinase that phosphorylates the C-terminal repeat domain of the largest subunit of RNA polymerase II". Proc. Natl. Acad. Sci. U.S.A. 86 (10): 3624–8. Bibcode:1989PNAS...86.3624L. doi:10.1073/pnas.86.10.3624. PMC 287190. PMID 2657724.