(4S)-limonene synthase

Not to be confused with (R)-limonene synthase.

(4S)-limonene synthase
Identifiers
EC no.	4.2.3.16
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

The enzyme (4S)-limonene synthase (EC 4.2.3.16) catalyzes the chemical reaction

geranyl diphosphate $\rightleftharpoons$ (−)-(4S)-limonene + diphosphate

This enzyme belongs to the family of lyases, specifically those carbon-oxygen lyases acting on phosphates. The systematic name of this enzyme class is geranyl-diphosphate diphosphate-lyase [cyclizing, (−)-(4S)-limonene-forming]. Other names in common use include (−)-(4S)-limonene synthase, 4S-(−)-limonene synthase, geranyldiphosphate diphosphate lyase (limonene forming), geranyldiphosphate diphosphate lyase [cyclizing,, and (4S)-limonene-forming]. This enzyme participates in monoterpenoid biosynthesis.

References

• Bohlmann J, Steele CL, Croteau R (1997). "Monoterpene synthases from grand fir (Abies grandis). cDNA isolation, characterization, and functional expression of myrcene synthase, (−)-(4S)-limonene synthase, and (−)-(1S,5S)-pinene synthase". J. Biol. Chem. 272 (35): 21784–92. doi:10.1074/jbc.272.35.21784. PMID 9268308.
• Colby SM, Alonso WR, Katahira EJ, McGarvey DJ, Croteau R (1993). "4S-limonene synthase from the oil glands of spearmint (Mentha spicata). cDNA isolation, characterization, and bacterial expression of the catalytically active monoterpene cyclase". J. Biol. Chem. 268 (31): 23016–24. PMID 8226816.
• Yuba A, Yazaki K, Tabata M, Honda G, Croteau R (1996). "cDNA cloning, characterization, and functional expression of 4S-(−)-limonene synthase from Perilla frutescens". Arch. Biochem. Biophys. 332 (2): 280–7. doi:10.1006/abbi.1996.0343. PMID 8806736.