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English: Figure 2. Representation of diagnostic strategy for patients suspected hereditary hemochromatosis (HH). * Recommendations report TS > 45%, SF > 200 μg/L in females and > 300 μg/L in males; or in advanced stages: TS > 50% in females and TS > 60% in males, in the absence of secondary causes [79,80]. ** Some patients with primary iron overload may not present mutation during this genetic approach. Very rare mutations in other genes can be involved [15,81]. Abbreviations: TS: transferrin saturation; SF: serum ferritin; JH: juveline hemochromatosis. + means positive result, and − means negative result.